βH‐spectrin is required for ratcheting apical pulsatile constrictions during tissue invagination
نویسندگان
چکیده
منابع مشابه
Uncoupling apical constriction from tissue invagination
Apical constriction is a widely utilized cell shape change linked to folding, bending and invagination of polarized epithelia. It remains unclear how apical constriction is regulated spatiotemporally during tissue invagination and how this cellular process contributes to tube formation in different developmental contexts. Using Drosophila salivary gland (SG) invagination as a model, we show tha...
متن کاملA Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.
Epithelial invagination is a common feature of embryogenesis. An example of invagination morphogenesis occurs during development of the early eye when the lens placode forms the lens pit. This morphogenesis is accompanied by a columnar-to-conical cell shape change (apical constriction or AC) and is known to be dependent on the cytoskeletal protein Shroom3. Because Shroom3-induced AC can be Rock...
متن کاملEndocytosis Is Required for Efficient Apical Constriction during Xenopus Gastrulation
Coordinated apical constriction (AC) in epithelial sheets drives tissue invagination [1, 2] and is required for diverse morphogenetic movements such as gastrulation [3], neurulation [4, 5], and organogenesis [6]. We showed previously that actomyosin contractility drives AC in Xenopus laevis bottle cells [7]; however, it remained unclear whether it does so in concert with other processes. Here w...
متن کاملIntegration of contractile forces during tissue invagination
Contractile forces generated by the actomyosin cytoskeleton within individual cells collectively generate tissue-level force during epithelial morphogenesis. During Drosophila mesoderm invagination, pulsed actomyosin meshwork contractions and a ratchet-like stabilization of cell shape drive apical constriction. Here, we investigate how contractile forces are integrated across the tissue. Reduci...
متن کاملCompartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis.
During development, small RhoGTPases control the precise cell shape changes and movements that underlie morphogenesis. Their activity must be tightly regulated in time and space, but little is known about how Rho regulators (RhoGEFs and RhoGAPs) perform this function in the embryo. Taking advantage of a new probe that allows the visualisation of small RhoGTPase activity in Drosophila, we presen...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2020
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201949858